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刘相国教授博士生导师电话:0531-88364330E-mail:xgliu@s.e.cn 教育背景中国科学院微生物研究所理学博士学位(微生物学),2000山东大学生命科学学院理学硕士学位(细胞生物学),1997山东大学生物系理学学士学位(生物学),1994 工作经历2008.8-现在,细胞生物学教授,博士生导师,学术带头人(第二层次),山东大学生命科学学院2003.9-2008.8,postdoctoralfellow,DepartmentofHematology/Oncology,WinshipCancerInstitute,EmoryUniversitySchoolofMedicine,Atlanta,GA,USA2002.11-2003.8,postdoctoralassociate,DepartmentofMolecularGeneticsandMicrobiology,CollegeofMedicine,UniversityofFlorida,Gainesville,FL,USA.2000.9-2002.11,博士后,北京大学医学部基础医学院免疫系。研究方向肿瘤细胞信号转导和抗肿瘤药物筛选:本研究组将以中国人高发肿瘤为研究对象,充分利用分子生物学,基因组学及蛋白质组学等技术,研究肿瘤细胞发生、发展和转移的分子机理;肿瘤细胞死亡的分子机制及信号转导;抗肿瘤药物的作用机制及抗肿瘤靶向药物筛选系统的构建等。研究成果及发表论文近年发表论文1.LinYD*,LiuX*,YueP,KhuriFR,SunSY.Involvementofc-FLIPandsurvivindownregulationinFlex-Het-incedapoptosisandenhancementofTRAIL-initiatedapoptosisinlungcancercells.MolecularCancerTher.2008.7(11):3556-3565.(*indicatingauthorsofequalcontribution).2.LiuX,YueP,ChenS,HuL,LonialS,KhuriFR,SunSY.TheProteasomeInhibitorPS-341(Bortezomib)Up-RegulatesDR5ExpressionLeadingtoInctionofApoptosisandEnhancementofTRAIL-IncedApoptosisDespiteUp-Regulationofc-FLIPandSurvivinExpressioninHumanNSCLCCells.CancerRes.2007May15;67(10):4981-8.3.LiuX,YueP,SchonthalAH,KhuriFR,SunSY.CellularFLICE-inhibitoryproteindown-regulationcontributestocelecoxib-incedapoptosisinhumanlungcancercells.CancerRes.2006Dec1;66(23):11115-9.4.LiuX,YueP,KhuriFR,SunSY.Decoyreceptor2(DcR2)isap53targetgeneandregulateschemosensitivity.CancerRes.2005.Oct15;65(20):9169-75.5.LiuX,YueP,ZhouZ,KhuriFR,SunSY.Deathreceptorregulationandcelecoxib-incedapoptosisinhumanlungcancercells.JNatlCancerInst.2004Dec1;96(23):1769-80.6.LiuX,YueP,KhuriFR,SunSY.p53upregulatesdeathreceptor4expressionthroughanintronicp53bindingsite.CancerRes.2004Aug1;64(15):5078-83.7.JinF*,LiuX*,ZhouZ,YueP,LotanR,KhuriFR,ChungLW,SunSY.Activationofnuclearfactor-kappaBcontributestoinctionofdeathreceptorsandapoptosisbythesyntheticretinoidCD437inDU145humanprostatecancercells.CancerRes.2005Jul15;65(14):6354-63.(*indicatingauthorsofequalcontribution)8.SunSY,LiuX,ZouW,YueP,MarcusAI,KhuriFR.ThefarnesyltransferaseinhibitorLonafarnibinceCHOP-dependentexpressionofdeathreceptor5leadingtoinctionofapoptosisinhumancancercells.JBiolChem.2007Jun29;282(26):18800-9.Epub2007May9.9.QiuY,LiuX,ZouW,YueP,LonialS,KhuriFR,SunSY.TheFarnesyltransferaseInhibitorR115777Up-regulatestheExpressionofDeathReceptor5andEnhancesTRAIL-IncedApoptosisinHumanLungCancerCells.CancerRes.2007May15;67(10):4973-80.10.ZouW,LiuX,YueP,ZhouZ,SpornMB,LotanR,KhuriFR,SunSY.c-JunNH2-terminalkinase-mediatedup-regulationofdeathreceptor5contributestoinctionofapoptosisbythenovelsynthetictriterpenoidmethyl-2-cyano–3,12-dioxooleana-1,9-dien-28-oateinhumanlungcancercells.CancerRes.2004Oct15;64(20):7570-8.11.ChangLJ,LiuX,HeJ.LentiviralsiRNAstargetingmultiplehighlyconservedRNAsequencesofhumanimmunodeficiencyvirustype1.GeneTher.2005Jul;12(14):1133-44.12.ChenS,LiuX,YueP,SchonthalAH,KhuriFR,SunSY.CHOP-dependentDR5inctionandubiquitin/proteasome-mediatedc-FLIPdownregulationcontributetoenhancementofTRAIL-incedapoptosisbydimethyl-celecoxibinhumannon-smallcelllungcancercells.MolPharmacol.2007Nov;72(5):1269-79.Epub2007Aug7.13.ZouW,LiuX,YueP,KhuriFR,SunSY.PPARgammaLigandsEnhanceTRAIL-incedApoptosisthroughDR5Upregulationandc-FLIPDownregulationinHumanLungCancerCells.CancerBiolTher.2007Jan29;6(1);6(1):99-106.14.ZouW,ChenS,LiuX,YueP,SpornMB.,KhuriFR.andSunSY.c-FLIPDownregulationContributestoApoptosisInctionbytheNovelSyntheticTriterpenoidMethyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate(CDDO-Me)inHumanLungCancerCells.CancerBiolTher.2007Oct;6(10).15.ZhangXY,LiuXG,WangW,WangWC,GaoXM.Anti-T-cellhumoralandcellularresponsesinhealthyBALB/cmicefollowingimmunizationwithovalbuminorovalbumin-specificTcells.Immunology.2003;108(4):465–473.16.ZhaoWP,LiuXG,WangW,GaoXM.LargequantityofribosomalRNAexistsextracellularlyinmousespleen.HistochemJ.2002,Aug-Sep;34(8-9):391-6.17.YangG,QiuB,LiuX,LiY,WangX.Nonsensemutationsofreplicaseandmovementproteingenescontributetotheattenuationofanavirulenttomatomosaicvirus.VirusRes.2002;87(2):119-128.18.LiuXG,WangW,LuY,GaoXM.TcellvaccinationincesregulatoryhumoralimmuneresponseinBALB/cmice.ChinJImmunol.(中国免疫学杂志).2002,18(9):604-607.19.LiuXG,YangG,QiuBS,TienP.ConstructionoffusiongeneofHBV(adr)surfaceantigendeterminantandBsubunitofCholeratoxinandhighlevelexpressioninE.coli.ActaMicrobiologicaSinica.(微生物学报),2001,41(5):625-629.20.LiuXG,YangG,QiuBS,TienP.ExpressionoftwotruncatedenhancingenefromHelicoverpaarmigeragranulosisvirusinE.coli.anditspreliminarybioassay,ActaMicrobiologicaSinica.(微生物学报).2001,41(2):167-172.21.LiuXG,YangG,QiuBS,TienP.RemovingunspecificantibodieswithsephacrylgelcouplingE.coli.proteinsbyperiodateoxidation.Microbiologica.(微生物学通报).2001,28(3):73-75.22.LiuXG,YangG,QiuBS,TienP.MolecularcloningofenhancingenefromHelicoverpaarmigeragranulosisvirusanditsexpressioninE.coli.ActaMicrobiologicaSinica.(微生物学报).2000,40(4):379-383.23.YangG,LiuXG,QiuBS.CompletenucleotidesequencesandstructureanalysisoftheinfectiouscDNAsoftobaccomosaicvirus(Chineseisolate,vulgarstrain)anditsattenuatedvaccine-N14(tomatostrain)genomes.Chin.J.Biotech.(生物工程学报)。.2000.16(4):437-442.24.YangG,LiuXG,QiuBS,RecombinantsconstructionandinfectivityanalysisoftobaccomosaicvirusandattenuatedtomatomosaicvirusN14genomes.Chinesesciencesbulletin.(科学通报).2000,45(15):1399-1404.25.ZhaoWPLiuXG,WangW,LvPZhangL,GaoXM.RelationshipBetweenRNAReleasedfromMouseApoptoticMurineSplenocytesandAutoimmuneDisease.ChineseJournalofBiochemistryandMolecularBiology.(中国生物化学和分子生物学杂志)2003,19(5):662-666.26.ZhangXY,HanSH,LiuXG,GaoXM,etal.TcellvaccinationincesregulatoryTcellresponseinBALB/cmice.ChinJMicrobiolImmunol.(中华微生物学免疫学杂志)2002,22(2):127-130.27.LiB,HanSH,LiuXG,GaoXM.TcellvaccinationagainstsystemiclupuserythematosusinBXSBmice.AcadJSecMilMedUniv.(第二军医大学学报)2002,23(10):1091-1096.综述性文章1.LiuX,SunSY.FLICEInhibitoryprotein.In:EncyclopediaofCancer(SecondEdition).2008.1131-1133.SpringerBerlinHeidelberg.ISBN:978-3-540-36847-2(Print)978-3-540-47648-1(Online)DOI:10.1007/978-3-540-47648-1-2208.*如果发现导师信息存在错误或者偏差,欢迎随时与我们联系,以便进行更新完善。联系方式>>
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刘巍峰教授博士生导师E-mail:weifliu@s.e.cn Cellulosicbiomassbioconversiongroup刘巍峰Wei
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林建群Jian-qunLin,PrincipalInvestigator,Professor,Ph.DDirectorVice-directorofStateKeyLab
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林建强教授博士生导师电话:0531-88365218E-mail:jianqianglin@s.e.cn 教育背景林建强男,1964年生,博士
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李越中教授博士生导师副院长电话:0531-88564288E-mail:lilab@s.e.cn教育背景李越中,男,1964年8月生,籍贯广东东莞,党派
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孔健教授博士生导师电话:0531-88364384转8401E-mail:kongjian@s.e.cn教育背景孔健,女,1964年7月生,博士,教授,200
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黄峰教授博士生导师电话:0531-88365311E-mail:fhuang@s.e.cn 教育背景黄峰,男,生于1961年5月,工学博士,现为山东
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侯丙凯教授博士生导师电话:0531-88364726;13864182973;传真:0531-88565610E-mail:bkhou@s.e.cn教育背景
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谷立川教授博士生导师电话:+86-531-88362039E-mail:lcgu@s.e.cn实验室主页:http://www.mbtech.s.e.cn/gulab/