刘相国教授博士生导师电话:0531-88364330E-mail:xgliu@s.e.cn 教育背景中国科学院微生物研究所理学博士学位（微生物学），2000山东大学生命科学学院理学硕士学位（细胞生物学），1997山东大学生物系理学学士学位（生物学），1994 工作经历2008.8-现在,细胞生物学教授,博士生导师,学术带头人(第二层次),山东大学生命科学学院2003.9-2008.8,postdoctoralfellow，DepartmentofHematology/Oncology,WinshipCancerInstitute,EmoryUniversitySchoolofMedicine,Atlanta,GA,USA2002.11-2003.8,postdoctoralassociate，DepartmentofMolecularGeneticsandMicrobiology,CollegeofMedicine,UniversityofFlorida,Gainesville,FL,USA.2000.9-2002.11,博士后,北京大学医学部基础医学院免疫系。研究方向肿瘤细胞信号转导和抗肿瘤药物筛选:本研究组将以中国人高发肿瘤为研究对象，充分利用分子生物学，基因组学及蛋白质组学等技术，研究肿瘤细胞发生、发展和转移的分子机理；肿瘤细胞死亡的分子机制及信号转导；抗肿瘤药物的作用机制及抗肿瘤靶向药物筛选系统的构建等。研究成果及发表论文近年发表论文1.LinYD*，LiuX*,YueP,KhuriFR,SunSY.Involvementofc-FLIPandsurvivindownregulationinFlex-Het-incedapoptosisandenhancementofTRAIL-initiatedapoptosisinlungcancercells.MolecularCancerTher.2008.7(11):3556-3565.(*indicatingauthorsofequalcontribution).2.LiuX,YueP,ChenS,HuL,LonialS,KhuriFR,SunSY.TheProteasomeInhibitorPS-341(Bortezomib)Up-RegulatesDR5ExpressionLeadingtoInctionofApoptosisandEnhancementofTRAIL-IncedApoptosisDespiteUp-Regulationofc-FLIPandSurvivinExpressioninHumanNSCLCCells.CancerRes.2007May15;67(10):4981-8.3.LiuX,YueP,SchonthalAH,KhuriFR,SunSY.CellularFLICE-inhibitoryproteindown-regulationcontributestocelecoxib-incedapoptosisinhumanlungcancercells.CancerRes.2006Dec1;66(23):11115-9.4.LiuX,YueP,KhuriFR,SunSY.Decoyreceptor2(DcR2)isap53targetgeneandregulateschemosensitivity.CancerRes.2005.Oct15;65(20):9169-75.5.LiuX,YueP,ZhouZ,KhuriFR,SunSY.Deathreceptorregulationandcelecoxib-incedapoptosisinhumanlungcancercells.JNatlCancerInst.2004Dec1;96(23):1769-80.6.LiuX,YueP,KhuriFR,SunSY.p53upregulatesdeathreceptor4expressionthroughanintronicp53bindingsite.CancerRes.2004Aug1;64(15):5078-83.7.JinF*,LiuX*,ZhouZ,YueP,LotanR,KhuriFR,ChungLW,SunSY.Activationofnuclearfactor-kappaBcontributestoinctionofdeathreceptorsandapoptosisbythesyntheticretinoidCD437inDU145humanprostatecancercells.CancerRes.2005Jul15;65(14):6354-63.(*indicatingauthorsofequalcontribution)8.SunSY,LiuX,ZouW,YueP,MarcusAI,KhuriFR.ThefarnesyltransferaseinhibitorLonafarnibinceCHOP-dependentexpressionofdeathreceptor5leadingtoinctionofapoptosisinhumancancercells.JBiolChem.2007Jun29;282(26):18800-9.Epub2007May9.9.QiuY,LiuX,ZouW,YueP,LonialS,KhuriFR,SunSY.TheFarnesyltransferaseInhibitorR115777Up-regulatestheExpressionofDeathReceptor5andEnhancesTRAIL-IncedApoptosisinHumanLungCancerCells.CancerRes.2007May15;67(10):4973-80.10.ZouW,LiuX,YueP,ZhouZ,SpornMB,LotanR,KhuriFR,SunSY.c-JunNH2-terminalkinase-mediatedup-regulationofdeathreceptor5contributestoinctionofapoptosisbythenovelsynthetictriterpenoidmethyl-2-cyano–3,12-dioxooleana-1,9-dien-28-oateinhumanlungcancercells.CancerRes.2004Oct15;64(20):7570-8.11.ChangLJ,LiuX,HeJ.LentiviralsiRNAstargetingmultiplehighlyconservedRNAsequencesofhumanimmunodeficiencyvirustype1.GeneTher.2005Jul;12(14):1133-44.12.ChenS,LiuX,YueP,SchonthalAH,KhuriFR,SunSY.CHOP-dependentDR5inctionandubiquitin/proteasome-mediatedc-FLIPdownregulationcontributetoenhancementofTRAIL-incedapoptosisbydimethyl-celecoxibinhumannon-smallcelllungcancercells.MolPharmacol.2007Nov;72(5):1269-79.Epub2007Aug7.13.ZouW,LiuX,YueP,KhuriFR,SunSY.PPARgammaLigandsEnhanceTRAIL-incedApoptosisthroughDR5Upregulationandc-FLIPDownregulationinHumanLungCancerCells.CancerBiolTher.2007Jan29;6(1);6(1):99-106.14.ZouW,ChenS,LiuX,YueP,SpornMB.,KhuriFR.andSunSY.c-FLIPDownregulationContributestoApoptosisInctionbytheNovelSyntheticTriterpenoidMethyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate(CDDO-Me)inHumanLungCancerCells.CancerBiolTher.2007Oct;6(10).15.ZhangXY,LiuXG,WangW,WangWC,GaoXM.Anti-T-cellhumoralandcellularresponsesinhealthyBALB/cmicefollowingimmunizationwithovalbuminorovalbumin-specificTcells.Immunology.2003;108(4):465–473.16.ZhaoWP,LiuXG,WangW,GaoXM.LargequantityofribosomalRNAexistsextracellularlyinmousespleen.HistochemJ.2002,Aug-Sep;34(8-9):391-6.17.YangG,QiuB,LiuX,LiY,WangX.Nonsensemutationsofreplicaseandmovementproteingenescontributetotheattenuationofanavirulenttomatomosaicvirus.VirusRes.2002;87(2):119-128.18.LiuXG,WangW,LuY,GaoXM.TcellvaccinationincesregulatoryhumoralimmuneresponseinBALB/cmice.ChinJImmunol.(中国免疫学杂志).2002,18(9):604-607.19.LiuXG,YangG,QiuBS,TienP.ConstructionoffusiongeneofHBV(adr)surfaceantigendeterminantandBsubunitofCholeratoxinandhighlevelexpressioninE.coli.ActaMicrobiologicaSinica.（微生物学报）,2001,41(5):625-629.20.LiuXG,YangG,QiuBS,TienP.ExpressionoftwotruncatedenhancingenefromHelicoverpaarmigeragranulosisvirusinE.coli.anditspreliminarybioassay,ActaMicrobiologicaSinica.（微生物学报）.2001,41(2):167-172.21.LiuXG,YangG,QiuBS,TienP.RemovingunspecificantibodieswithsephacrylgelcouplingE.coli.proteinsbyperiodateoxidation.Microbiologica.（微生物学通报）.2001,28(3):73-75.22.LiuXG,YangG,QiuBS,TienP.MolecularcloningofenhancingenefromHelicoverpaarmigeragranulosisvirusanditsexpressioninE.coli.ActaMicrobiologicaSinica.（微生物学报）.2000,40(4):379-383.23.YangG,LiuXG,QiuBS.CompletenucleotidesequencesandstructureanalysisoftheinfectiouscDNAsoftobaccomosaicvirus(Chineseisolate,vulgarstrain)anditsattenuatedvaccine-N14(tomatostrain)genomes.Chin.J.Biotech.（生物工程学报）。.2000.16(4):437-442.24.YangG,LiuXG,QiuBS,RecombinantsconstructionandinfectivityanalysisoftobaccomosaicvirusandattenuatedtomatomosaicvirusN14genomes.Chinesesciencesbulletin.（科学通报）.2000,45(15):1399-1404.25.ZhaoWPLiuXG,WangW,LvPZhangL,GaoXM.RelationshipBetweenRNAReleasedfromMouseApoptoticMurineSplenocytesandAutoimmuneDisease.ChineseJournalofBiochemistryandMolecularBiology.（中国生物化学和分子生物学杂志）2003,19(5):662-666.26.ZhangXY,HanSH,LiuXG,GaoXM,etal.TcellvaccinationincesregulatoryTcellresponseinBALB/cmice.ChinJMicrobiolImmunol.（中华微生物学免疫学杂志）2002,22(2):127-130.27.LiB,HanSH,LiuXG,GaoXM.TcellvaccinationagainstsystemiclupuserythematosusinBXSBmice.AcadJSecMilMedUniv.（第二军医大学学报）2002,23(10):1091-1096.综述性文章1.LiuX,SunSY.FLICEInhibitoryprotein.In:EncyclopediaofCancer(SecondEdition).2008.1131-1133.SpringerBerlinHeidelberg.ISBN：978-3-540-36847-2(Print)978-3-540-47648-1(Online)DOI：10.1007/978-3-540-47648-1-2208.*如果发现导师信息存在错误或者偏差，欢迎随时与我们联系，以便进行更新完善。联系方式>>

刘巍峰教授博士生导师E-mail:weifliu@s.e.cn Cellulosicbiomassbioconversiongroup刘巍峰Wei

林建群Jian-qunLin,PrincipalInvestigator,Professor，Ph.DDirectorVice-directorofStateKeyLab

林建强教授博士生导师电话:0531-88365218E-mail:jianqianglin@s.e.cn 教育背景林建强男，1964年生，博士

李越中教授博士生导师副院长电话:0531-88564288E-mail:lilab@s.e.cn教育背景李越中，男，1964年8月生，籍贯广东东莞，党派

孔健教授博士生导师电话：0531－88364384转8401E-mail:kongjian@s.e.cn教育背景孔健，女，1964年7月生，博士，教授，200

黄峰教授博士生导师电话:0531-88365311E-mail:fhuang@s.e.cn 教育背景黄峰，男，生于1961年5月，工学博士，现为山东

侯丙凯教授博士生导师电话：0531-88364726；13864182973；传真：0531-88565610E-mail：bkhou@s.e.cn教育背景

谷立川教授博士生导师电话:+86-531-88362039E-mail:lcgu@s.e.cn实验室主页：http://www.mbtech.s.e.cn/gulab/